Routine immunohistochemistry study for polyomavirus BK nephropathy in transplanted kidney biopsies, is it recommended?
نویسندگان
چکیده
منابع مشابه
BK Polyomavirus and the Transplanted Kidney: Immunopathology and Therapeutic Approaches
BK polyomavirus is ubiquitous, with a seropositivity rate of over 75% in the adult population. Primary infection is thought to occur in the respiratory tract, but asymptomatic BK virus latency is established in the urothelium. In immunocompromised host, the virus can reactivate but rarely compromises kidney function except in renal grafts, where it causes a tubulointerstitial inflammatory respo...
متن کاملPolyomavirus Bk Infection in Pediatric Kidney-
patients. Am J Transplant 2001; 1: 385 (A 991). 12. Niemeyer G, Koch M, Light S, et al. Long-term safety, tolerability and efficacy of daclizumab (Zenapax) in a two-dose regimen in liver transplant recipients. Am J Transplant 2002; 2: 454. 13. Gaber AO, Gaber LW, Shokouh-Amiri MH, et al. Percutaneous biopsy of pancreas transplants. Transplantation 1992; 54: 548. 14. Nashan B, Light S, Hardie IR...
متن کاملEarly BK polyomavirus (BKV) reactivation in donor kidney is a risk factor for development of BKV-associated nephropathy.
The pathogenesis of BK polyomavirus (BKV) infection and associated nephropathy in renal transplant recipients is not clearly understood. To gain insight, urine and plasma samples were collected from 112 renal transplant recipients before and after transplantation and tested for the presence of BKV by polymerase chain reaction. Detection of BKV infection very early (ie, 5 days) after transplanta...
متن کاملPolyomavirus BK-specific immunity after kidney transplantation.
Failure to mount or maintain a protective immune response may influence the development of polyomavirus BK (BKV)-associated nephropathy (PVAN). However, limited data are so far available on BKV-specific immunity after kidney transplantation. BKV-specific cellular immune response was retrospectively analyzed in kidney recipients with or without BKV infection/reactivation by measuring the frequen...
متن کاملFrequency of Polyomavirus BK Infection in Kidney Transplant Patients Suspected to Nephropathy
BACKGROUND Polyomavirus BK is a major cause of nephropathy in immunosuppressed transplanted patients. Non-invasive diagnostic protocols such as molecular detection of polyomavirus BK replication are a useful strategy to predict BK virus-associated nephropathy (BKVAN). OBJECTIVE To determine the prevalence of polyomavirus BK infection among kidney transplant patients suspected to have BKVAN. ...
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ژورنال
عنوان ژورنال: BMC Nephrology
سال: 2021
ISSN: 1471-2369
DOI: 10.1186/s12882-021-02444-5